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A Polymorphism in the Human Timeless Gene is not Associated with Diurnal Preferences In Normal Adults

Mario Pedrazzoli¹, Lin Ling¹, Laurel Finn², Terry Young², Daniel Katzenberg¹ and Emmanuel Mignot¹.
¹Center for Narcolepsy, Department of Psychiatry, Stanford University
²Department of Preventive Medicine University of Wisconsin-Madison The effect of a single nucleotide polymorphism, a glutamine to arginine amino acid substitution in the human Timeless gene (Q831R, A2634G), on diurnal preferences was studied in a random sample of normal volunteers enrolled in a population-based epidemiology study of the natural history of sleep disorders. We genotyped 528 subjects for this single nucleotide polymorphism and determined morningness-eveningness tendencies using the Horne-Ostberg questionnaire. Our results indicate that Q831R Timeless has no influence on morningness-eveningness tendencies in humans.